Contraindicated (one)pentobarbital will minimize the level or effect of roflumilast by affecting hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital will reduce the level or outcome of tofacitinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check. Loss of, or reduced response to tofacitinib may perhaps come about whe